CLINICAL
PERSPECTIVE
BY DAVID
ACHESON, M.D.
Dr. David Acheson is the Director
of The Food Safety Initiative (FSI) at the New England Medical
Center in Boston. FSI has a faculty of more than 20 medical
doctors, scientists, veterinarians and public health experts.
FSI provides its food industry clients with timely medical and
scientific analyses of food-borne pathogens and food-borne
disease.
C. jejuni Infection and the Link with
Guillian-Barré Syndrome
A
well-known cause of gastroenteritis, C. jejuni now has been
found to be responsible for GBS, a major systemic disease that
is the most common cause of acute flaccid paralysis. The link
provides an interesting illustration of the hidden dangers of
foodborne infections, and why scientists and epidemiologists
need to be aware of both their immediate and long-term
consequences.
Different types of Campylobacter
have been linked with disease in
humans, but by far the type most commonly associated with
foodborne disease is Campylobacter jejuni. C. jejuni is now
considered to be the most common bacterial cause of foodborne
disease in the US, with approximately 2.5 million cases per year,
based on recent estimates from the Centers for Disease Control.
Yet, C. jejuni is a relative newcomer to the field of foodborne
pathogens; it was first described in the mid-1970s and it took a
while before it gained wide recognition as a significant cause of
disease in humans. One contributing factor is that it is a
difficult organism to culture and development of routine
diagnostics tests was slow to come on line.
C. jejuni causes gastroenteritis that is
often indistinguishable from the other classic foodborne bacterial
pathogens such as Salmonella and Escherichia coli. However, in
recent years it has become clear that this organism has a much
more sinister side to it in the form of a major complication in
some patients following the gastrointestinal infection. I refer,
of course, to Guillian-Barré syndrome (GBS). We will discuss what
is known about the link between C. jejuni and GBS in the second
part of this article. First, however, we will look at the typical
clinical presentation of an acute infection with C. jejuni.
Acute Infection with C. jejuni
C. jejuni bacteria are found in fowl and
many wild and domestic animals, and most human infections probably
result from contamination of milk and other animal food sources,
especially poultry. The organisms can also be transmitted by
direct contact with infected animals or contaminated water.
Cross-contamination between infected poultry and other foods is
probably one of the most frequent modes of transmission. Small
numbers of organisms can cause disease; as few as 500 have been
shown to cause infection in some volunteer studies. But the
problem with these studies is that they are usually done in
healthy young adults rather than a high-risk population. As with
many other foodborne pathogens, C. jejuni infections are more
common in the summer months.
The incubation period for C. jejuni
infection varies, typically between one and seven days, with most
cases occurring two to four days after exposure. Very short
incubation periods of less than 12 hours have been reported.
Illness typically begins with fever, headache, muscle aches and
malaise for up to 24 hours before intestinal symptoms develop. The
infection initially appears much like the beginnings of an attack
of the flu then typically develops into a more classical
gastroenteritis with nausea, abdominal pain, vomiting and diarrheamore
in line with the symptoms one experiences with Salmonella or E.
coli. The fever can be high, up to 104°F, and the diarrhea can be
copious. Blood is frequently present in the stool but varies in
amount. The illness usually lasts less than a week, but patients
untreated with antibiotics frequently continue to excrete the
organisms for several weeks.
Not all C. jejuni infections require
antibiotics, and antibiotic treatment should be reserved for the
more severe cases. One of the recent worrying trends with C.
jejuni is the increasing number of isolates that are resistant to
the standard first-line antibiotics used to treat diarrheal
disease. This is becoming a major problem, especially in
infections that are acquired overseas. Person-to-person spread is
not generally considered to be a major concern with Campylobacter,
so treating to prevent this is not generally recommended, except
in the case of food handlers. There can, however, be exceptions to
this; for example, the reduction of spread in daycare settings.
C. jejuni are generally considered to be
invasive bacteria, which means they have the capacity to get
inside the cells lining the intestinal tract. This results in
local inflammation and tissue damage, and this is one of the
factors that is thought to be important in the development of
bloody diarrhea in some patients. However, the bacteria usually
remain confined to the cells of the intestinal tract and it is
unusual for them to invade the blood stream.
The natural history of C. jejuni
infection in most individuals is that it will settle spontaneously
without the need for specific treatment. However, as with all
diarrheal diseases, it is important to pay attention to adequate
hydration. Occasionally the bacteria do get into the blood stream
and can then infect other parts of the body, such as heart valves
(endocarditis), the gall bladder (cholecystitis) and the pancreas
(pancreatitis). As with other foodborne pathogens, such as
Salmonella, Shigella and Yersina, another complication following
Campylobacter infection is a condition known as reactive
arthritis. This follows several weeks after the acute infection
and is more common in certain groups of people who have a specific
tissue type known as HLA-B27. Of course, one of the more feared
complications following C. jejuni infection is the development of
GBS.
Guillian-Barré Syndrome What Is it?
Guillian-Barré syndrome is a disease
that affects the peripheral nerves, which run from the spinal cord
to individual muscles, as opposed to the brain, that control the
arms, legs and body. Patients with GBS have flaccid paralysis,
meaning their muscles and limbs become floppy and unusable. This
is in contrast to spastic paralysis that typically follows a
stroke when arms and legs become stiff and unusable through damage
to the brain itself. Since the control of polio, GBS is the most
common cause of acute flaccid paralysis.
Patients who develop GBS will experience
a progressive weakness that usually begins in their feet and
gradually extends up the body in a symmetrical pattern. This will
evolve over a period of days and will lead to an inability to walk
and loss of the use of arms. If it spreads far enough up the body,
then it can result in paralysis of the respiratory muscles leading
to an inability to breathe. Clearly this is a major complication
that can result in patients requiring mechanical ventilation for a
period of time.
The progression is usually rapid and may
take only a matter of days to progress from the first signs of
difficulty in walking to a need for a breathing machine. The
weakness usually reaches a peak within two to three weeks of the
beginning of the disease and then typically there is a gradual
recovery that may take weeks or even months. The chances that GBS
will progress to requiring mechanical ventilation is around 20%
and although the majority of people will make a full recovery, 15%
to 20% of patients have some residual physical problems. Modern
medical intensive-care support has reduced the mortality rate from
GBS, but even now 2% to 3% of patients with GBS will die from the
disease, often due to complications that arise during the acute
part of the disease when patients are paralyzed and require
intensive medical support.
The link between C. jejuni and GBS was
first described in 1982 in a 45-year-old man. In recent years the
link has become stronger and it is now clear that 30% to 40% of
GBS cases are related to a prior infection with C. jejuni. Still,
the risk of developing GBS following infection with C. jejuni is
quite low and current estimates are that one person will develop
GBS for each 1,000 people infected with C. jejuni. There are, in
fact, approximately 100 different serotypes of C. jejuni, not all
of which are equally likely to lead to GBS. Strain O:19 is one
that is frequently associated with GBS but at least 11 other
serotypes also have been linked to the disease.
How Is GBS Linked with C. jejuni?
In order to address the question of how
GBS and C. jejuni infection in the intestine are linked, I first
want to say a little about what causes the initial nerve damage.
Peripheral nerves that run to and from the spinal cord to muscles
are composed of a mixture of motor nerves and sensory nerves. Each
nerve is covered in an insulating material called myelin that is
important to enabling the electrical impulses to move along the
nerves at speeds approaching 2,500 feet per second. The principal
problem in GBS is that the patient's immune system begins to
attack the myelin surrounding the nerves, which dramatically
affects the nerve's ability to function.
The myelin is composed of various
molecules. One of the major constituents is polysaccharides, which
are made up of a string of different types of sugar molecules. The
C. jejuni bacterium has the same string of sugars on its outer
coat, as illustrated in the figure on the facing page. Thus, when
a person is infected with C. jejuni, the body regards this
bacterium as foreign and begins to generate an immune response to
the invader. Unfortunately, these same antibodies that are made to
bind to the sugars on the outer coat of the organism also bind to
the sugars on the myelin. This process is known as molecular
mimicry.
After antibodies have bound to the myelin
coating, a series of events is initiated that includes the arrival
of new immune cells that begin to attack the myelin. This
interferes with the nerve function and, as a result, leads to the
clinical manifestations of GBS.
In some patients GBS follows very rapidlyoften
in less than a weekafter the gastrointestinal infection. This is
probably because the patient already had some antibodies present
from a previous exposure to C. jejuni but not at a high enough
level to cause problems. Then following a second infection the
exposure to C. jejuni acts like a booster to the immune response,
leading to the rapid development of GBS as the antibody levels
quickly rise to a point where they can bind to the myelin and
begin to interfere with nerve function. This concept is important
in view of current attempts to make vaccines against Campylobacter:
clearly one does not want to make a Campylobacter vaccine that can
lead to the production of antibodies that increase the likelihood
of getting GBS following a natural C. jejuni infection.
This evolving story of how a bacterium
that was thought to cause a straightforward gastroenteritis but is
now found to be responsible for major systemic disease is an
interesting illustration of the hidden dangers of foodborne
infections. Clearly, it is important for clinicians,
epidemiologists and food scientists to be aware of both the
immediate and long-term consequences of foodborne infections.
There are many other examples of how different foodborne pathogens
can lead to both an immediate upset, usually in the form of
gastroenteritis, and then reappear in some format in a much more
dangerous or even life-threatening way. Future articles will
address some of the other food-borne pathogens that can cause such
unexpected complications.
Other Changes To Make
-
drink 6-8 glasses of steam distilled or
filtered water a day
-
eat 50% raw fruits and vegetables (organic is best)
-
nuts, seeds, and whole grains are good
-
juice is good (make your
own with a juice machine)
-
do not worry as much about calories as eating the right foods
-
carrot and celery sticks are good to use as a snack
-
a colon cleansing can be very helpful - (do several times each year)
-
do not drink coffee, alcohol, soda pop, other junk food drinks
-
do not eat processed foods white sugar, white flour, etc...
-
use stress relief like going for walks in the park
(or the 10/90 rule - see
Stress)
-
brown rice is good to eat
-
avoid red meat and animal fats
-
reduce dairy products cheese, milk, and others
-
fast a few days a month
-
get at least 8 hours of sleep
-
exercise light to moderate amounts
-
avoid artificial sweeteners like Aspartame and NutraSweet
-
do not smoke and avoid second hand smoke
-
do not skip meals - just eat better and not as much at each meal
-
do not chew gum - it can cause you to feel hungry
-
do not watch too much TV try reading a book or something else
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